Mark J. Holterman, Medical

Three Patient Benefits of Cellular Therapies


Mark J Holterman
Mark J Holterman

A pediatric surgeon with more than two decades of experience, Mark Holterman, MD, teaches medical students and residents at the University of Illinois College of Medicine and serves as the chief medical officer for Mariam Global Health. Dr. Mark Holterman also maintains an interest in stem cell therapy and has published numerous articles on the subject. Stem cell therapies offer multiple benefits to patients, as outlined below.

1. Treats a wide range of conditions. From cardiovascular and neurodegenerative diseases to orthopedic injuries, cellular therapies can treat a broad spectrum of medical conditions. Research indicates that cellular therapies can help stimulate the repair and growth of blood vessel tissues surrounding the heart and offer relief from degenerative symptoms associated with neurodegenerative diseases. Medical researchers also suspect that adult stem cells may possess the ability to help patients with autoimmune diseases and diabetes.

2. Promotes wound healing. Stem cell therapy accelerates tissue growth and boosts the body’s production of collagen, a protein found in skin, muscles, bones, blood vessels, and the digestive system that strengthens skin and replaces dead cells. The increase of collagen concentration tightens damaged tissue and reduces scars by growing healthy tissue.

3. Improved success for transplants. Cellular therapies give patients the option to transplant cells from one area of their body to another, which decreases the possibility of a rejection response.

Mark J. Holterman, Medical

IPSAC-VN International Scholar Program



As a professor of surgery and pediatrics at the University of Illinois College of Medicine, Mark Holterman, MD, PhD, conducts medical research and teaches medical students and surgical residents. Dr. Mark Holterman also supports the International Pediatric Specialists Alliance for the Children of Vietnam (IPSAC-VN).

IPSAC-VN endeavors to improve the care of children in Vietnam by enhancing health care, using education and training to increase workforce and institutional capacity, supporting academics, contributing material and equipment, and providing surgery in the remote highlands. The IPSAC-VN International Scholar Program helps to accomplish this objective by awarding $2,500 to licensed and in-training medical personnel for educational expenses, travel, and room and board while spending up to two months being educated in the United States. This education involves observing clinical practices or receiving training in transnational research at a medical institution accredited by the Accreditation Council for Graduate Medical Education (ACGME).

The program is tailored to each chosen scholar who has the goal of enhancing the quality of health care at his or her institution in Vietnam. At the end of the program, all scholars prepare a presentation that details the practices they will carry out to improve patient care.

Mark J. Holterman, Medical

Programs of Excellence Deliver Pediatric Teaching and Patient Care


Programs of Excellence pic
Programs of Excellence

Mariam Global Health CEO and chief medical officer Mark Holterman, MD, possesses more than two decades of experience in pediatric medicine and surgery. Dr. Mark Holterman also serves as a professor of pediatrics and surgery at the University of Illinois College of Medicine, which administers the Programs of Clinical Excellence through its Pediatrics Department.

The Programs of Clinical Excellence engage in various aspects of pediatric medicine, from providing comprehensive medical care to offering students multi-level professional education. The program’s staff consists of a diverse medical team that advances the pediatric discipline with basic and clinical research into childhood diseases. Staff members commit to delivering compassionate, high-quality health care and serve as forerunners for the advancement of medical arts and sciences, while using the latest advancements in patient care, research, and teaching.

A dedicated advocate for child health, the collection of programs also facilitates community involvement in improving the health of children across the state. The program promotes the use of preventive and educational methods and upholds the rights of children to access quality health care and outcomes. Furthermore, the programs serve as a resource for families and physicians throughout the community.

The Programs of Clinical Excellence administers 10 initiatives that include the Comprehensive Sickle Cell Center, Pediatric Renal Transplantation Program, the Pediatric Diabetes Program, and the Thriving Illinois Kids Engagement System. The other areas include neonatology, pediatric lung research, management of chronic conditions via CHECK, pediatric neurological and developmental disorders, asthma, and follow-ups for longtime survivors of childhood cancer.

Community Outreach, Mark J. Holterman

IPSAC-VN Improving Vietnamese Healthcare with Scholarship Program



An experienced pediatric surgeon Mark Holterman, MD, has maintained concurrent responsibilities as professor of surgery and pediatrics at the University of Illinois College of Medicine and as CEO of Mariam Global Health for the last five years. An active member of his field, Dr. Mark Holterman supports the work of the International Pediatric Specialists Alliance for the Children of Vietnam (IPSAC-VN).

Since its inception, IPSAC-VN has worked toward the goal of sustainably improving pediatric medicine for the youngest residents of Vietnam. To this end, the organization operates several initiatives that provide medical personnel, supplies, and other needed resources to the region.

IPSAC-VN also supports this need by operating its International Scholar Program, which connects local medical professionals with opportunities to obtain further education at learning institutions in the United States. To qualify for the scholarship, applicants must furnish a letter from their current institution to highlight their dedication to health care improvement.

All IPSAC-VN scholars receive $2,500 to fund their travels to the United States, where they spend up to two months at a host medical institution. During this period, they either train in medical research or participate in clinical examinations. At the close of the scholarship program, participants return to their institution in Vietnam and speak in front of IPSAC-VN supporters. This presentation must cover both their time abroad and the methods they plan to use in their enhancement of local pediatric health care.

Mark J. Holterman, Medical

ADA and CHLA Team Up to Tackle Type 2 Diabetes in Young People


 CHLA pic

A medical school graduate of the University of Virginia, Mark Holterman, MD, teaches surgery and pediatrics at the University of Illinois College of Medicine. Committed to the advancement of medicine and finding a cure for chronic health conditions such as diabetes, Dr. Mark Holterman belongs to the American Diabetes Association (ADA).

In early September, the ADA announced a joint initiative with Children’s Hospital Los Angeles to address the increasing rate of type 2 diabetes occurring in children and teenagers. The two organizations have developed an experience called Camp PowerUp, which utilizes an evidence-based curriculum to engage youth in physical activities and teach them how to make healthier food choices, in order to lower their risk of developing type 2 diabetes.

The program will target young people between the ages of eight and 16 in a range of settings, from day camps and after-school programs to churches and parks. With the experience that the two organizations bring to the table in terms of diabetes care and childhood medicine, they believe programs such as this can help stop the rise of type 2 diabetes in this vulnerable age group.

Mark J. Holterman, Medical

21st Century Cures Act Supports Regenerative Medicine


21st Century Cures Act pic
21st Century Cures Act

Mark Holterman, MD, a pediatric surgeon, has served as a member of the general surgical team at Children’s Hospital at OSF Healthcare since 2011. He is additionally a professor in the Division of Pediatric Surgery at the University of Illinois College of Medicine in Peoria. Dr. Mark Holterman, CEO of regenerative medicine-focused Mariam Global Health, maintains a strong interest in the development of cell-based therapies.

In late 2016, the United States Congress passed and President Obama signed the 21st Century Cures Act. This legislation, the result of bi-partisan alliances in Congress, was designed to help patients with serious health conditions benefit from the fast-tracking of new drugs and medical devices. It also channels new funds into medical research. In addition to its $2 billion designated over a two-year period to fight the American opioid epidemic, and other provisions, the law provides greater support to the field of regenerative medicine.

The act builds on the Food and Drug Administration’s recent practice of incorporating the input of patients into the agency’s drug approval procedures. Thus, it provides for a quicker and more efficient FDA approval process for certain stem cell treatments before they enter the market. The membership of groups such as the World Stem Cell Summit and the Alliance for Regenerative Medicine applauded the new legislation.

Mark J. Holterman, Medical

Treatment Goals for SJIA


Dr. Mark J. Holterman pic
Dr. Mark J. Holterman

Yale University alumnus Mark Holterman, MD is a successful pediatrician and surgeon with over two decades of experience. He currently holds a full professorship position at the University of Illinois College of Medicine where he is an active surgeon inthe division of pediatric surgery. Dr. Mark Holterman was one of the minds behind the establishment of non-profit organization The Hannah Sunshine Foundation.

The Hannah Sunshine Foundation is an organization that focuses on the use of cellular and regenerative therapies for children with rare diseases. It was inspired by three young people, one of which was Sarah Hughes, a 23-year-old woman afflicted with systemic juvenile idiopathic arthritis (SJIA).

SJIA is a serious subtype of juvenile idiopathic arthritis (JIA). Unlike other types of JIA, the condition not only affects the joints but also involves other organs such as the heart, liver, and lungs. The condition is rare and only occurs among 10 to 20 percent of all children who have some form of JIA.

The disease has no known cure as of yet, but treatment is available. Doctors managing the disease focus on achieving permanent remission – a state wherein there are no clinical signs and symptoms that the disease is still active. Due to the damage that it may bring the joints, experts believe that early, aggressive treatment during the active phase of the disease should be encouraged.